Yes, Trintellix can affect an operation with the risks of bleeding. Medications that act on serotonin, like Trintellix, can decrease platelet aggregation, which is needed to stop bleeding during surgery. However, in most cases, antidepressants like Trintellix will not be stopped before surgery unless there are other risk factors present. It is important to use Advil cautiously before surgery, as it can also affect platelet aggregation and potentially cause irritation to the digestive system. It is recommended to use the smallest effective dose of Advil for the shortest duration possible.