Antidepressants can sometimes cause weight gain as a side effect, but not all of them do. It appears that Cipralex is less likely to cause weight gain compared to other medications in the same class. One possible reason for weight gain while taking Cipralex could be that the medication is effectively treating your anxiety, which may have initially caused a loss of appetite. It's important to maintain a healthy lifestyle with proper nutrition and exercise to help manage anxiety and limit any weight gain.