Hello, it would be appropriate to take Benadryl to relieve itching and hives. However, it should be noted that Benadryl can cause drowsiness and that you should not drive after taking the medication. The adult dose is 50 mg every 4 to 6 hours, I don't know what formulation you have but if it is the children's liquid (6.25 mg of diphenhydramine in 5 ml, check by reading the side of the box) you will need 40 ml to make the 50 mg dose. If your symptoms do not improve despite taking Benadryl and Reactine, it would be best to consult a doctor. Also, it would be appropriate to take an allergy test in the near future to confirm the cause of your allergy. Finally, as additional tips, you can apply cold water compresses and put on NON-FRAGRANT moisturizing cream to relieve your itching. If you have any questions, do not hesitate to contact me or your pharmacist. Kind regards.