It is possible to take muscle relaxants with your other medications, however, you should be aware of the ingredients in the over-the-counter formulas. Ibuprofen, Naproxen, and other anti-inflammatory drugs should be avoided. Combinations of muscle relaxants and acetaminophen, such as Robaxacet, are compatible with your other medications. However, it is important to note that muscle relaxants can cause drowsiness, and when combined with hydromorphone, you should be extra cautious when engaging in activities that require alertness and avoid alcohol. If you have any further questions, please do not hesitate to reach out.