I give Nystatin (for thrush) to my baby, it says to give 4 times a day, does the dose absolutely need to be followed by a breastfeeding within 10 minutes?

Yes, Nystatin cream does not require a prescription and is safe to use on your baby if they come into contact with their mouth after application. It is recommended to follow the prescribed dosage and continue with your breastfeeding schedule. If you have cracked nipples, it is also appropriate to apply the cream on them.