It is not recommended to apply mupirocin cream on a cold sore, as it is an antibiotic for bacterial infections and cold sores are caused by a virus. Antiviral medications for cold sores are usually prescribed by a doctor. You can try washing the affected area gently with soap and water, keeping your hands clean, and moisturizing the area with Vaseline to prevent drying. Cold sores typically last about 2 weeks.
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