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If I take 20 mg of Vyvanse daily, can I develop a tolerance?

It is unlikely that taking Vyvanse 20 mg daily will lead to developing a tolerance. Tolerance is when the body becomes accustomed to a medication and requires higher doses for the same effect. However, it is possible that over time, your symptoms may not be as well managed with the same dose and an increase in dosage may be needed. This is not necessarily due to tolerance.