If over-the-counter pain relief is needed for menstrual cramps, acetaminophen (such as Tylenol) is a suitable option. It is recommended to stick to the recommended dosage and not exceed it. If ibuprofen is used too frequently, there is a risk of developing stomach ulcers or irritation. In that case, it's advisable to consult a healthcare provider about using proton pump inhibitors to protect the stomach while taking anti-inflammatory medication.