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Are there any disadvantages to taking antihistamines every day and developing a tolerance to them?

Taking antihistamines every day can lead to developing a tolerance to the medication, making it less effective over time. It is important to follow the recommended dosage and speak with a healthcare professional if you have concerns about long-term use. Some antihistamines, such as second-generation ones like Claritin, Reactine, and Aerius, are considered safe for long-term use. It is always best to consult with a healthcare provider for personalized advice.