Are there any risks in taking Tylenol 1g and Advil 400mg every 4 hours instead of every 6 hours for 48 hours because the pain becomes unbearable after 4 hours?

It is generally safe to take Tylenol 1g every 4 hours and Advil 400 mg every 4 hours for up to 48 hours, as long as you do not exceed the recommended daily dosage. If the pain continues to be unbearable even after taking these medications, it is important to consult a dentist to determine the cause of the pain and possibly consider a stronger pain reliever.