It is important to ensure that the cream is in contact with the infected skin. To do this, you can create a small reservoir by pulling the foreskin forward and applying the cream through the urinary meatus. Gently massage the skin over the glans to help the cream spread. To reduce pain, take an over-the-counter pain reliever such as Tylenol or Advil 2-3 hours before application and apply cold in the minutes before application for additional pain relief.